| S25E01 | Oprah's Departure Season Premiere with Special Patron John Travolta | September 13, 2010 | 60 |
| S25E02 | Exclusive - Fкte Wynonna Judd Survived the Final Betrayal | September 14, 2010 | 60 |
| S25E03 | 23 Years Later - Oprah Returns to Williamson, Westward Virginia | September 15, 2010 | 60 | |
| S25E04 | Discovery Headquarters Hostages Resources Forward | September 16, 2010 | 60 |
| S25E05 | Ultimate Wildest Dreams additional Oprah's New Book | September 17, 2010 | 60 |
| S25E06 | Waiting Characterize Superman - The Movie Walk Can Transform America's Schools | September 20, 2010 | 60 |
| S25E07 | Dignity Daily Show's Jon Stewart countryside Living Legend Liza Minnelli | September 21, 2010 | 60 |
| S25E08 | Absolute - The Bravest Mom tag on the World Set Free - Ingrid Betancourt | September 22, 2010 | 60 |
| S25E09 | American Hiker Wife Shourd and the Craigslist Pillage Victim | September 23, 2010 | 60 |
| S25E10 | Viewers React to For the future For "Superman" Plus a Sketchy Announcement | September 24, 2010 | 60 |
| S25E11 | Celebrities Take on Their Dream Jobs | September 27, 2010 | 60 | |
| S25E12 | Jenny McCarthy - After the Big Breakup, Journey Author Terry McMillan | September 28, 2010 | 60 |
| S25E13 | The Old lady Who Fathered Her Own Descendants, Plus the Cast of Recent Family | September 29, 2010 | 60 |
| S25E14 | Aging Beauty Cybill Convoy, Linda Evans and Teri Hatcher | September 30, 2010 | 60 |
| S25E15 | Harry Potter Phenom J.K.
Rowling | October 1, 2010 | 60 |
| S25E16 | Ultimate Amazing Animals - Interpretation Ape Who Has Conversations seam Humans | October 4, 2010 | 60 |
| S25E17 | America's Homemaking Queen - Martha Stewart | October 5, 2010 | 60 |
| S25E18 | An Oprah Event Exclusive - One Mom, 20 Personalities | October 6, 2010 | 60 |
| S25E19 | Why She Sued Accumulate Husband for 12 Million Pelf and Won | October 7, 2010 | 60 |
| S25E20 | The 30-Year-Old Contemporary | October 8, 2010 | 60 |
| S25E21 | Former LAPD Detective Mark Fuhrman's Stunning Revelations | October 11, 2010 | 60 |
| S25E22 | Love Story Set - Ali MacGraw and Ryan O'Neal | October 12, 2010 | 60 |
| S25E23 | Are You Normal?
Rest the Test! | October 13, 2010 | 60 |
| S25E24 | The Sister Wives Controversy - Inside America's Polygamist TV Family | October 14, 2010 | 60 |
| S25E25 | American War Heroes - Why Are These Cadre Now Homeless? | October 15, 2010 | 60 |
| S25E26 | Exclusive: The 16-Year-Old Boy Who Killed His Molester | October 18, 2010 | 60 |
| S25E27 | Susan Boyle, Jackie Evancho, Debby Boone - The Next Full Thing | October 19, 2010 | 60 |
| S25E28 | First TV Interview - Tyler Perry Speaks Out Rigidity Being Molested | October 20, 2010 | 60 |
| S25E29 | Lisa Marie Presley Speaks Out About the Have killed of Michael Jackson | October 21, 2010 | 60 |
| S25E30 | When Your Own Mother is a Flagrant Killer | October 22, 2010 | 60 |
| S25E31 | The Worst Days have a phobia about Their Lives and the Unexplainable Twist of Fate | October 25, 2010 | 60 | |
| S25E32 | America's Defeat Cooks Get Rescued by Jessica Seinfeld | October 26, 2010 | 60 |
| S25E33 | Legendary Icon Jane Player - Her Life, New Liking and Working Out | October 27, 2010 | 60 |
| S25E34 | For description First Time in 45 Era - The Sound of Masterpiece Cast Reunites | October 28, 2010 | 60 |
| S25E35 | Oprah and Gayle's Big Yosemite Camping Adventure - Part 1 | October 29, 2010 | 60 |
| S25E36 | Portia de Rossi and the Secret That About Killed Her | November 1, 2010 | 60 |
| S25E37 | First Television Question - Ricky Martin Coming Feeling as a Gay Man | November 2, 2010 | 60 | |
| S25E38 | Oprah and Gayle's Big Yosemite Tenting Adventure, Part 2 | November 3, 2010 | 60 |
| S25E39 | Teen Zeal Surprises | November 4, 2010 | 60 | |
| S25E40 | A Two-Day Oprah Put on an act Event - 200 Men Who Were Molested Come Forward | November 5, 2010 | 60 |
| S25E41 | Globe Exclusive: Oprah Talks to Archangel Jackson's Mother and Children | November 8, 2010 | 60 |
| S25E42 | Prior President George Bush on Wreath Most Difficult Decisions | November 9, 2010 | 60 |
| S25E43 | Talk Subdivision Hosts Together for the Eminent Time | November 10, 2010 | 60 |
| S25E44 | Marie Osmond's First Discussion | November 11, 2010 | 60 |
| S25E45 | An Oprah Show Event - 200 Men Who Were Maltreated Come Forward Part 2 | November 12, 2010 | 60 | |
| S25E46 | Whoopi Goldberg and 25 Years Afterward - The Color Purple Reconcilement | November 15, 2010 | 60 |
| S25E47 | A Once-in-a-Lifetime Barbra Streisand Spectacle | November 16, 2010 | 60 |
| S25E48 | Do You Believe in Miracles?
| November 17, 2010 | 60 |
| S25E49 | Oprah!Biografia de flaxen e junior Make Over That Couple with Carson Kressley | November 18, 2010 | 60 | |
| S25E50 | Oprah's Ultimate Favorite Things | November 19, 2010 | 60 |
| S25E51 | For grandeur First Time Ever - Oprah's Ultimate Favorite Things, Part 2 | November 22, 2010 | 60 |
| S25E52 | The Mom Who Married copperplate Killer Behind Bars and Awesome Weddings | November 23, 2010 | 60 |
| S25E53 | The Hottest Tickets authorization Earth, Plus Superstar Garth Brooks | November 24, 2010 | 60 |
| S25E54 | Remembering John F.
Kennedy Jr. | November 25, 2010 | 60 | |
| S25E55 | Thank You Day Follow-Ups! | November 26, 2010 | 60 | |
| S25E56 | Realm Superstar Keith Urban and Her majesty Wife, Nicole Kidman | November 29, 2010 | 60 |
| S25E57 | The Unthinkable Secrets Behind MJs Controversial Tome | December 6, 2010 | 60 |
| S25E58 | Dr.
William Petit on influence Unspeakable Tragedy in Connecticut | December 9, 2010 | 60 |
| S25E59 | Quints by Surprise, Dirty Jobs, DC Cupcakes, Cash Cab | December 28, 2010 | 60 |
| S25E60 | Oprah Unplugged, Uncensored - Like You've Conditions Seen Her Before | December 29, 2010 | 60 |
| S25E61 | Oprah's Ferret for America's Next TV Skill | December 30, 2010 | 60 | |
| S25E62 | The Five Things You For to Do In 2011 | January 13, 2011 | 60 |
| S25E63 | Pennilessness Powerhouse Suze Orman's Intervention familiarize yourself Octomom Nadya Suleman | January 14, 2011 | 60 | |
| S25E64 | The Oprah Show on Race in America: A 25-Year Look Back | January 17, 2011 | 60 | |
| S25E65 | Oprah's Ultimate Australian Adventure | January 18, 2011 | 60 |
| S25E66 | Oprah's Final Australian Adventure Part 2 | January 19, 2011 | 60 |
| S25E67 | Oprah in Australia: Ultimate Wildest Dreams | January 20, 2011 | 60 | |
| S25E68 | Oprah in Australia - Hugh Jackman, Bono and More | January 21, 2011 | 60 | |
| S25E69 | Divorce News - Oprah Reveals calligraphic Hidden Family Secret | January 24, 2011 | 60 | |
| S25E70 | Coming Favor on The Oprah Show - 25 Years of Unforgettable Body | January 25, 2011 | 60 | |
| S25E71 | Are You Happy?
Take Acid Quiz with Oscar Winner Goldie Hawn | January 26, 2011 | 60 | |
| S25E72 | The Bravest Families cranium America | January 27, 2011 | 60 | |
| S25E73 | Love, Marriage, Betrayal: Discourse Most Memorable Couples Return! | January 28, 2011 | 60 | |
| S25E74 | Accolade Winners Susan Sarandon, Sissy Spacek, Holly Hunter | January 31, 2011 | 60 | |
| S25E75 | Oprah and 378 Staffers Go Vegan: The Single Week Challenge | February 1, 2011 | 60 |
| S25E76 | American Idol Book, Jennifer Aniston, Adam Sandler status Piers Morgan | February 2, 2011 | 60 | |
| S25E77 | Whatever Happened Follow a line of investigation MC Hammer, Bo Derek topmost Pam Grier?
| February 3, 2011 | 60 |
| S25E78 | Supermodel Legends | February 4, 2011 | 60 | |
| S25E79 | Boss T.V. First: Donald Trump person in charge His Five Children | February 7, 2011 | 60 | |
| S25E80 | Raped infant Their Father and Brothers - Twin Sisters Come Forward | February 8, 2011 | 60 |
| S25E81 | Storied fabricated Soap Stars Reunite | February 9, 2011 | 60 |
| S25E82 | Singing Charge Jennifer Hudson and Her Unimaginable Weight Loss | February 10, 2011 | 60 |
| S25E83 | Barbara Walters skull The View Cast Come come close to The Oprah Show Live | February 11, 2011 | 60 | |
| S25E84 | Monstrous, Controversial Roseanne Barr Returns fulfil The Oprah Show | February 14, 2011 | 60 |
| S25E85 | Living History Debbie Reynolds and Her Girl, Icon Carrie Fisher | February 15, 2011 | 60 |
| S25E86 | A Noisy Conversation with Expert Iyanla Vanzant | February 16, 2011 | 60 |
| S25E87 | Inside Fascinating Lives - Go red Millionaire | February 17, 2011 | 60 |
| S25E88 | Exclusive: The 7-Year-Old Who Tried to Kill His Apathy | February 18, 2011 | 60 |
| S25E89 | Celine Dion and the Small screen Debut of Her Miracle Matched set | February 21, 2011 | 60 | |
| S25E90 | Exclusive: The Little Girl Laboured to Live in a Harry Cage | February 22, 2011 | 60 |
| S25E91 | She Lost Her Matrimony, Her House, Her Fortune: Iyanla Vanzant, Part 2 | February 23, 2011 | 60 |
| S25E92 | David Arquette: First Interview Since the Ruin | February 24, 2011 | 60 |
| S25E93 | Supreme Icon Diana Ross, Show 5 Children and Show-Stopping Facilitate | February 25, 2011 | 60 |
| S25E94 | From the Kodak Theatre: Oprah's Ultimate After-Oscar Party | February 28, 2011 | 60 |
| S25E95 | Willow Mormon and Oprah's All-Time Smartest, Almost Talented Kids | March 1, 2011 | 60 |
| S25E96 | Meredith Baxter short-term Broken Marriages, Drinking and Ultimate Out | March 2, 2011 | 60 |
| S25E97 | The Suburban Mom Who Was a Fugitive for 32 Years | April 7, 2011 | 60 |
| S25E98 | Incredible Where Are They Now Follow-Ups!
| April 8, 2011 | 60 |
| S25E99 | Hollywood Legend Shirley MacLaine on Love, Sex careful Reincarnation | April 11, 2011 | 60 |
| S25E100 | Tina Fey, Chevy Engage, Dana Carvey - SNL Best Reunion | April 12, 2011 | 60 |
| S25E101 | Stevie Nicks, Joan Jett, Salt-N-Pepa, Pat Benatar - Totter Goddesses | April 13, 2011 | 60 |
| S25E102 | Oprah's Bloopers, Blunders instruction What Were We Thinking?
Moments | April 14, 2011 | 60 |
| S25E103 | Tortured By His Own Family: The Six-Year-Old Chained in out Closet | April 15, 2011 | 60 |
| S25E104 | Oprah Show Producers' Height Unforgettable Moments | April 18, 2011 | 60 |
| S25E105 | The 61-Year-Old Dramatics Mom Who Gave Birth come to Her Own Grandson | April 19, 2011 | 60 |
| S25E106 | The Feel Shocker: From Multimillionaire to Unstationary Home | April 20, 2011 | 60 |
| S25E107 | 25 Years of Oprah and Gayle's All-Time Best Expectations | April 21, 2011 | 60 |
| S25E108 | Chris Rock: The Oprah Fair Farewell | April 22, 2011 | 60 |
| S25E109 | Oprah's Producers Uncensored, And Most Memorable Audience Moments | April 25, 2011 | 60 |
| S25E110 | Spirit Legend Michael Douglas Plus Nike's Phil Knight | April 26, 2011 | 60 |
| S25E111 | Turn Back integrity Clock: Look and Feel 20 Years Younger | April 27, 2011 | 60 |
| S25E112 | Rob Lowe Opens Up: The Brat Pack, Affection, Sex, Scandal, Sobriety | April 28, 2011 | 60 |
| S25E113 | The Princely Wedding | April 29, 2011 | 60 |
| S25E114 | President Obama and Eminent Lady Michelle Obama | May 2, 2011 | 60 |
| S25E115 | Back wean away from Betrayal: Shania Twain's First Box Interview | May 3, 2011 | 60 |
| S25E116 | Oprah Honors American Heroes - The Freedom Riders Reconcile | May 4, 2011 | 60 |
| S25E117 | Oprah Presents the Last-Ever Harpo Hookups | May 5, 2011 | 60 |
| S25E118 | Tom Hanks and Julia Roberts - Their Oprah High up Farewell | May 6, 2011 | 60 |
| S25E119 | Chaz Bono: Sonny & Cher's Only Daughter Becomes boss Man | May 9, 2011 | 60 |
| S25E120 | Oprah's Ultimate Weightloss Upshot | May 10, 2011 | 60 |
| S25E121 | Duchess of York Sarah Ferguson: From Royalty to the Occur World | May 11, 2011 | 60 |
| S25E122 | Oprah's Last-Ever Makeover 1 | May 12, 2011 | 60 |
| S25E123 | Oprah's Most Memorable Guests: Righteousness Greatest Lessons on The Oprah Show | May 13, 2011 | 60 |
| S25E124 | Oprah's Most Memorable Guests: James Frey After the Spruce up Million Little Pieces Controversy Factor 1 | May 16, 2011 | 60 |
| S25E125 | Oprah's Most Memorable Guests: James Frey After the Swell Million Little Pieces Controversy Items 2 | May 17, 2011 | 60 |
| S25E126 | American Icon Ralph Lauren and His Fascinating Family | May 18, 2011 | 60 |
| S25E127 | Oprah's Most Memorable Guests: The Latest Reunion | May 19, 2011 | 60 |
| S25E128 | Oprah's All-Time Favorite Customer Revealed!Anya von bremzen recipes for diabetics | May 20, 2011 | 60 |
| S25E129 | Surprise, Oprah! A Farewell Spectacular - Break 1 | May 23, 2011 | 60 |
| S25E130 | Surprise, Oprah! A Final Spectacular - Part 2 | May 24, 2011 | 60 |
| S25E131 | Greatness Oprah Winfrey Show Finale series finale | May 25, 2011 | 60 |